HAGENFORDA.COM

Methylation is a biochemical reaction of the body, the cardiovascular, endocrine, immune and detoxification, DNA / RNA structure and function, and other important metabolic control of energy production supports. It is a common problem in many individuals with autism spectrum. There are few effective treatments, namely methylcobalamin treatment (injection, oral, sublingual), methylation and other supplements such as TMG and DMG.

The two most cited chemical reactions in this system of re-methylation and trans-sulfuration.

Re-methylation (or methylation) – This route involves the conversion of homocysteine ​​to methionine. Methionine is a limiting factor for the production of other chemicals needed that affect the heart and blood vessels, muscles, immune system and nervous system. Is the conversion of homocysteine ​​to methionine by direct transfer of a methyl group (CH3) groups, Methylcobalamin (B12) or betaine (trimethylglycine or TMG) ​​occur.

Homocysteine ​​is sitting at an intersection of two different biochemical reactions. Because of its position in this matrix, the biochemical capacity, all methylation and metabolism of sulfur has an impact process transfer group in the body. Trans-sulfuration – this way is degrading homocysteine ​​to two different amino acids – cysteine ​​and taurine. Taurine is the most widely known for supporting heart and liver support, detoxification, formation of bile acids and cholesterol excretion. Glutathione is a powerful antioxidant and has far reaching effects on the protection of DNA / RNA, the heavy metal detoxification and immune function. Many children on the autistic spectrum have defects of both taurine and cysteine.

There are many intermediate steps in these two important biochemical reactions involved. Imagine a wheel that rotates continuously in a clockwise direction. Homocysteine ​​is the clock is 6 and methionine by 12 clock. This keeps the wheel turning in the right direction. Some other chemicals on the impacts of wheels at certain points. Methylcobalamin are activated folic acid (also known as methyl-folate) and betaine (TMG) is responsible for homocysteine ​​to methionine by the clock 06 clock 12. If a system is broken (methylcobalamin / folic acid) and betaine (TMG) can help. SAMe (S-adenosylmethionine) of the body “universal methyl donor” allows homocysteine ​​to methionine from 12:00 to 6:00. The problem with many autistic people is that this system works really hard not to compromise their immune, nervous and detoxification. The impact can be enormous, including the increase in detoxifying chronic infections, the inability of the body of chemicals and heavy metals, toxins and neuro-cognitive problems such as speech processing, attention , concentration and focus. There is a genetic component in many autistic people seem to have a problem with this methylation and trans-sulfuration chemistry.